I'm speaking specifically about the A:TLA ones; they are just...lame. I have never seen one that has made me go, "Oh! How charming and witty! Another bland attempt at sarcasm regarding certain peoples' choices of pairings in a cartoon! This person is obviously very talented with their screenshot cut-and-paste skills! OMG +FAV!" I think what just gets on my nerves is when I look at someone's gallery, and 90% of it is motivational posters made with A:TLA screenshots, as if that's some form of fanart. Guess what, people: it's utter crap. Absolutely nothing to be proud of. At least make a freaking attempt to draw something or come up with a decent joke, instead piling all this cut and pasted garbage all over the place.
Sad thing is, I don't think this fad is ever going to end. The internet is just a disgusting and horrible place...*sigh*